MW 421.3 Da, Purity >98%. Store-operated Ca²+ entry blocker. Potent, selective CRAC channel inhibitor. Inhibits thapsigargin-induced sustained Ca²+ influx (IC₅₀ = 100 nM). Suppresses cytokine production. Potent T-cell antiproliferative agent (IC₅₀ = 12.7 nM). Shows immunomodulatory and anti-inflammatory effects in vivo. Orally active.
The product is subject to the following: Abcam Restricted Use Statement